Reassessing the Role of Intra-Arterial Drug Delivery for Glioblastoma Multiforme Treatment

Intra-arterial ACNU and cisplatin chemotherapy for the treatment of glioblastoma multiforme.

Intra-arterial (IA) chemotherapy has achieved no obvious clinical superiority as a treatment for glioblastoma multiforme despite the many theoretical advantages. The clinical courses of 38 patients who underwent surgery and radiotherapy with IA 1-(4-amino-2-methyl-5-pyrimidinyl)-methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU) and cisplatin were reviewed. Tumor regrowth was evaluated...

A DNA Computer for Glioblastoma Multiforme Diagnosis and Drug Delivery

Glioblastoma multiforme (GBM) is a debilitating malignant brain tumor with expected patient survival of less than a year and limited responsiveness to most treatments, often requiring biopsy for diagnosis and invasive surgery for treatment. We propose a DNA computer system, consisting of input, computation, and output components, for diagnosis and treatment. The input component will detect the ...

Drug repurposing for the treatment of glioblastoma multiforme

BACKGROUND Glioblastoma Multiforme is the deadliest type of brain tumor and is characterized by very poor prognosis with a limited overall survival. Current optimal therapeutic approach has essentially remained unchanged for more than a decade, consisting in maximal surgical resection followed by radiotherapy plus temozolomide. MAIN BODY Such a dismal patient outcome represents a compelling n...

Possible role for furazolidone in the treatment of glioblastoma multiforme.

Drug cocktails for effective treatment of glioblastoma multiforme.

Waldemar Debinski, MD, PhD Director of Brain Tumor Center of Excellence, Comprehensive Cancer Center of Wake Forest University, Departments of Neurosurgery, Radiation Oncology, & Cancer Biology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA Tel.: +1 336 716 9712 Fax: +1 336 713 7639 [email protected] “Just about everything that relates to gl...